알츠하이머병 비임상 효능시험센터
국가 법령 정보센터 행정규칙에 따라 "인간의 건강에 미치는 시험물질의 성질이나 안전성에 관한 각종 자료를 얻기 위하여 실험실적 조건하에서 시험계를 사용하여 실시하는 시험"을 의미합니다.
즉, 동물, 세포를 대상으로 후보물질의 독성과 유효성을 평가하는 단계입니다!
가지고 계신 물질 또는 약물의 알츠하이머병 치료 효능과 기전을 확인하고 싶으신가요?
국내 최고의 알츠하이머병 치료제 후보물질의 비임상효능 시험 전문 센터! "건양대학교 알츠하이머병 비임상 효능시험센터"로 의뢰해주세요.
A chronic neurodegenerative disease that usually starts slowly and worsens over time. It is the cause of 60% to 70% of cases of dementia. The cause of Alzheimer's disease is poorly understood. No treatments stop or reverse its progression, though some may temporarily improve symptoms.
In 2015, there were approximately 29.8 million people worldwide with AD.
Adult neurogenesis poses many implications in terms of its functioning in learning and memory, emotion, stress, depression, and other conditions.
In humans, new neurons are continually born throughout adulthood in two regions of the brain: (1) the subgranular zone (SGZ) is part of the dentate gyrus of the hippocampus and (2) the subventricular zone (SVZ) is located throughout the lateral wall of the lateral ventricles.
The reduction of neurogenesis in SGZ causes cognitive defects and depression. In addition, the reduction of neurogenesis of the SVZ causes neuron replacement deficit of the cerebral cortex and sulcus olfactorius, affecting neuroplasticity.
A connectome is a comprehensive map of neural connections in the brain, and may be thought of as its "wiring diagram". More broadly, a connectome would include the mapping of all neural connections within an organism's nervous system.
Also known as lenomorelin (INN), it is a peptide hormone produced by ghrelinergic cells in the gastrointestinal tract which functions as a neuropeptide in the central nervous system.Besides regulating appetite, ghrelin also plays a significant role in regulating the distribution and rate of use of energy.
Unlike the case of many other endogenous peptides, ghrelin is able to cross the blood-brain-barrier, giving exogenously-administered ghrelin unique clinical potential.
Nuclear receptor, Nurr1
NURR1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
Natural products sometimes have therapeutic benefit as traditional medicines for treating diseases, yielding knowledge to derive active components as lead compounds for drug discovery. Although natural products have inspired numerous U.S. Food and Drug Administration-approved drugs, drug development from natural sources has received declining attention by pharmaceutical companies, partly due to unreliable access and supply, intellectual property concerns, seasonal or environmental variability of composition, and loss of sources due to rising extinction rates.